Phospho-FANCG (Ser383) Antibody - #AF0055

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产品: 磷酸化 FANCG (Ser383) 抗体
货号: AF0055
描述: Rabbit polyclonal antibody to Phospho-FANCG (Ser383)
应用: WB IHC
反应: Human, Mouse, Rat
分子量: 69kDa; 69kD(Calculated).
蛋白号: O15287
RRID: AB_2834098

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
Phospho-FANCG (Ser383) Antibody detects endogenous levels of FANCG only when phosphorylated at Sersine 383.
RRID:
AB_2834098
引用格式: Affinity Biosciences Cat# AF0055, RRID:AB_2834098.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

DNA repair protein XRCC9; FAG; FANCG; FANCG_HUMAN; Fanconi anaemia complementation group G; Fanconi anemia group G protein; Protein FACG; X ray repair, complementing defective, in Chinese hamster cells 9; X-ray repair, complementing defective, in Chinese hamster, 9; XRCC9;

抗原和靶标

免疫原:

A synthesized peptide derived from human FANCG around the phosphorylation site of Ser383.

Uniprot:

O15287(FANCG_HUMAN) >>Visit HPA database.

基因/基因ID:
FANCG(2189)
表达:
O15287 FANCG_HUMAN:

Highly expressed in testis and thymus. Found in lymphoblasts.

描述:
FANCG DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. Note: This description may include information from UniProtKB.
序列:
MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL

翻译修饰 - O15287 作为底物

Site PTM Type Enzyme
S7 Phosphorylation
K28 Ubiquitination
K182 Ubiquitination
K258 Ubiquitination
K347 Ubiquitination
S383 Phosphorylation P06493 (CDK1)
S387 Phosphorylation P06493 (CDK1)
K430 Ubiquitination
T487 Phosphorylation P06493 (CDK1)
K491 Ubiquitination
K504 Ubiquitination
T557 Phosphorylation
K559 Ubiquitination
K618 Ubiquitination

研究背景

功能:

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.

细胞定位:

Nucleus. Cytoplasm.
Note: The major form is nuclear. The minor form is cytoplasmic.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Highly expressed in testis and thymus. Found in lymphoblasts.

亚基结构:

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. When phosphorylated at Ser-7, forms a complex with BRCA2, FANCD2 and XRCC3.

研究领域

· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.

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