产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0465, RRID:AB_2834337.
展开/折叠
Down-regulated in colon cancer 1; DRCC1; FLJ20063; MUC 13; MUC-13; Muc13; MUC13 Down regulated in colon cancer 1; MUC13_HUMAN; Mucin 13, cell surface associated; Mucin-13; PRO20221; RECC; UNQ6194;
抗原和靶标
Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.
- Q9H3R2 MUC13_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKAIIHLTLLALLSVNTATNQGNSADAVTTTETATSGPTVAAADTTETNFPETASTTANTPSFPTATSPAPPIISTHSSSTIPTPAPPIISTHSSSTIPIPTAADSESTTNVNSLATSDIITASSPNDGLITMVPSETQSNNEMSPTTEDNQSSGPPTGTALLETSTLNSTGPSNPCQDDPCADNSLCVKLHNTSFCLCLEGYYYNSSTCKKGKVFPGKISVTVSETFDPEEKHSMAYQDLHSEITSLFKDVFGTSVYGQTVILTVSTSLSPRSEMRADDKFVNVTIVTILAETTSDNEKTVTEKINKAIRSSSSNFLNYDLTLRCDYYGCNQTADDCLNGLACDCKSDLQRPNPQSPFCVASSLKCPDACNAQHKQCLIKKSGGAPECACVPGYQEDANGNCQKCAFGYSGLDCKDKFQLILTIVGTIAGIVILSMIIALIVTARSNNKTKHIEEENLIDEDFQNLKLRSTGFTNLGAEGSVFPKVRITASRDSQMQNPYSRHSSMPRPDY
翻译修饰 - Q9H3R2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K308 | Ubiquitination | Uniprot | |
| K468 | Ubiquitination | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| S482 | Phosphorylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| Y501 | Phosphorylation | Uniprot | |
| S502 | Phosphorylation | Uniprot | |
| S506 | Phosphorylation | Uniprot | |
| Y512 | Phosphorylation | Uniprot |
研究背景
Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds.
Highly N-glycosylated.
Cell membrane>Single-pass type I membrane protein. Apical cell membrane. Secreted.
Note: Also exists as a soluble form.
Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.
Homodimer of beta subunits.
限制条款
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