(2)
(2)
| 产品: | ZKSCAN3 抗体 |
| 货号: | DF7752 |
| 描述: | Rabbit polyclonal antibody to ZKSCAN3 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 分子量: | 61 kDa; 61kD(Calculated). |
| 蛋白号: | Q9BRR0 |
| RRID: | AB_2841218 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7752, RRID:AB_2841218.
展开/折叠
dJ874C20.1; mszf35; SCAN-KRAB-zinc finger protein; Skz1; Zf47; Zfp-47; ZFP306; Zfp307; Zfp47; Zinc finger and SCAN domain containing protein 13; Zinc finger and SCAN domain-containing protein 13; Zinc finger protein 306; Zinc finger protein 306, isoform CRA_a; Zinc finger protein 307; Zinc finger protein 309; Zinc finger protein 47 homolog; Zinc finger protein with KRAB and SCAN domains 3; Zinc finger protein with KRAB and SCAN domains 3; Zinc finger protein zfp47; Zinc finger with KRAB and SCAN domains 3; ZKSC3_HUMAN; ZKSCAN3; ZNF309; ZSCAN13; ZSCAN35;
抗原和靶标
- Q9BRR0 ZKSC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARELSESTALDAQSTEDQMELLVIKVEEEEAGFPSSPDLGSEGSRERFRGFRYPEAAGPREALSRLRELCRQWLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPESGEEVVVLLEYLERQLDEPAPQVSGVDQGQELLCCKMALLTPAPGSQSSQFQLMKALLKHESVGSQPLQDRVLQVPVLAHGGCCREDKVVASRLTPESQGLLKVEDVALTLTPEWTQQDSSQGNLCRDEKQENHGSLVSLGDEKQTKSRDLPPAEELPEKEHGKISCHLREDIAQIPTCAEAGEQEGRLQRKQKNATGGRRHICHECGKSFAQSSGLSKHRRIHTGEKPYECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKAFSHSSDLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHRIHTGEKPYQCSMCGKAFRRSSHLLRHQRIHTGDKNVQEPEQGEAWKSRMESQLENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPYQCNACGKGFTRISYLVQHQRSHVGKNILSQ
翻译修饰 - Q9BRR0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y54 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| K82 | Methylation | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| T207 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| T224 | Phosphorylation | Uniprot | |
| T228 | Phosphorylation | Uniprot | |
| T337 | Phosphorylation | Uniprot | |
| T365 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot | |
| T421 | Phosphorylation | Uniprot | |
| T449 | Phosphorylation | Uniprot | |
| Y480 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| K515 | Acetylation | Uniprot |
研究背景
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
Nucleus. Cytoplasm.
Note: Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.
Belongs to the krueppel C2H2-type zinc-finger protein family.
文献引用
Application: WB Species: Pig Sample: adipose
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