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| 产品: | Defensin alpha1 抗体 |
| 货号: | DF8527 |
| 描述: | Rabbit polyclonal antibody to Defensin alpha1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 分子量: | 10 kDa; 10kD(Calculated). |
| 蛋白号: | P59665 |
| RRID: | AB_2841731 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8527, RRID:AB_2841731.
展开/折叠
DEF1; DEF3; DEFA1; DEFA2; DEFA3; Defensin alpha 1; Defensin alpha 2; Defensin alpha 3; HNP1; HNP3; HP1; HP3; MRS; Neutrophil defensin 1; Neutrophil defensin 2; Neutrophil defensin 3;
抗原和靶标
- P59665 DEF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMACYCRIPACIAGERRYGTCIYQGRLWAFCC
翻译修饰 - P59665 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y67 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| C83 | S-Nitrosylation | Uniprot | |
| Y85 | Phosphorylation | Uniprot |
研究背景
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.
Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation.
Secreted.
Dimer. Interacts with RETN.
Belongs to the alpha-defensin family.
文献引用
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