产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0187, RRID:AB_2833380.
展开/折叠
Constitutive photomorphogenic homolog subunit 3; COP 9 (constitutive photomorphogenic) subunit 3; COP 9 complex homolog subunit 3; COP 9 complex S3; COP 9 complex subunit 3; COP 9 constitutive photomorphogenic homolog subunit 3; COP 9 homolog; COP 9 signalosome complex subunit 3; COP 9 signalosome subunit 3; COP 9 subunit 3; COP9 (constitutive photomorphogenic) subunit 3; COP9 complex homolog subunit 3; COP9 complex S3; COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 homolog; COP9 signalosome complex subunit 3; COP9 signalosome subunit 3; COP9 subunit 3; COPS 3; cops3; CSN 3; CSN3; CSN3_HUMAN; JAB 1 containing signalosome subunit 3; JAB1 containing signalosome subunit 3; JAB1-containing signalosome subunit 3; SGN 3; SGN3; Signalosome subunit 3;
抗原和靶标
- Q9UNS2 CSN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UNS2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| Y227 | Phosphorylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| S273 | Phosphorylation | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| Y367 | Phosphorylation | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot |
研究背景
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cytoplasm. Nucleus.
Widely expressed. Expressed at high level in heart and skeletal muscle.
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 isoform 1. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG. Interacts with ERCC6.
Belongs to the CSN3 family.
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