GSDMD Antibody - #DF12275

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产品: GSDMD 抗体
货号: DF12275
描述: Rabbit polyclonal antibody to GSDMD
应用: WB IHC IF/ICC
文献验证: WB, IHC, IF/ICC
反应: Human
预测: Pig, Bovine, Horse, Dog
蛋白号: P57764
RRID: AB_2845080

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
GSDMD Antibody detects endogenous levels of total GSDMD.
RRID:
AB_2845080
引用格式: Affinity Biosciences Cat# DF12275, RRID:AB_2845080.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

1810036L03Rik; DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; Gasdermin D; Gasdermin domain containing 1; Gasdermin domain containing protein 1; Gasdermin domain-containing protein 1; Gasdermin-D; GasderminD; GSDMD; GSDMD_HUMAN; GSDMDC 1; GSDMDC1;

抗原和靶标

免疫原:

A synthesized peptide derived from human GSDMD.

基因/基因ID:
GSDMD(79792)

研究领域

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

文献引用

1). NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024 (PubMed: 39225315) [IF=15.1]
2). Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles. Bone research, 2024 (PubMed: 38383487) [IF=14.3]
3). Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization. Journal of Neuroinflammation, 2023 (PubMed: 36609266) [IF=9.3]
4). HSP90-regulated mitophagy can alleviate heat stress damage by inhibiting pyroptosis in the hepatocytes of Wenchang chickens. International journal of biological macromolecules, 2024 (PubMed: 39332550) [IF=7.7]
5). New Insights into Baicalein’s Effect on Chlorpyrifos-Induced Liver Injury in Carp: Involving Macrophage Polarization and Pyropto sis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2023 (PubMed: 36848483) [IF=5.7]
6). Acetyl-11-Keto-β-Boswellic Acid Accelerates the Repair of Spinal Cord Injury in Rats by Resisting Neuronal Pyroptosis with Nrf2. International journal of molecular sciences, 2023 (PubMed: 38203528) [IF=5.6]

Application: IF/ICC    Species: Rat    Sample:

Figure 4. AKBA Attenuates Expression of Neural Pyroptotic Effector Proteins. (A) β3-tubulin and GSDMD immunofluorescence double staining images. (B) β3-tubulin relative fluorescence intensity. (C) GSDMD relative fluorescence intensity. (D) GSDMD/β3-tubulin relative fluorescence intensity. The ** donated p < 0.01, *** donated p < 0.001, and **** donated p < 0.0001.
7). Staphylococcus pseudintermedius induces pyroptosis of canine corneal epithelial cells by activating the ROS-NLRP3 signalling pathway. Virulence, 2024 (PubMed: 38515339) [IF=5.5]
8). Shionone alleviates NLRP3 inflammasome mediated pyroptosis in interstitial cystitis injury. International Immunopharmacology, 2021 (PubMed: 33223465) [IF=4.8]
9). Exogenous NADPH could mitigate pyroptosis-induced brain injury in fetal mice exposed to gestational intermittent hypoxia. International immunopharmacology, 2024 (PubMed: 38781607) [IF=4.8]
10). Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis. Journal of ethnopharmacology, 2024 (PubMed: 38479543) [IF=4.8]
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