| 产品: | KLF10 抗体 |
| 货号: | DF13112 |
| 描述: | Rabbit polyclonal antibody to KLF10 |
| 应用: | WB |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 51 kDa; 53kD(Calculated). |
| 蛋白号: | Q13118 |
| RRID: | AB_2846072 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13112, RRID:AB_2846072.
展开/折叠
Early growth response, alpha; Early growth response, alpha like; EGR A; EGR alpha; EGR(A); EGR-alpha; EGRA; Egral; EGRalpha; Gdnfif; KLF 10; KLF10; KLF10_HUMAN; Krueppel like factor 10; Krueppel like factor10; Krueppel-like factor 10; Kruppel like factor 10; mGIF; TGF-beta- inducible early gene; TGFB inducible early growth response 1; TGFB inducible early growth response; TGFB inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG 1; TIEG; TIEG-1; TIEG1; Transforming growth factor beta inducible early growth response; Transforming growth factor beta inducible early growth response protein 1; Transforming growth factor-beta-inducible early growth response protein 1; Zinc finger transcription factor TIEG;
抗原和靶标
- Q13118 KLF10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLNFGASLQQTAEERMEMISERPKESMYSWNKTAEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPAPSTVHFKSLSDTAKPHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKAASILNYQNNSFRRRTHLNVEAARKNIPCAAVSPNRSKCERNTVADVDEKASAALYDFSVPSSETVICRSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVVSPNGTRLSPIAPAPGFSPSAAKVTPQIDSSRIRSHICSHPGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPTPAPTQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13118 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K32 | Ubiquitination | Uniprot | |
| T66 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | P04049 (RAF1) | Uniprot |
| S97 | Phosphorylation | Uniprot | |
| K135 | Sumoylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| K149 | Sumoylation | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K223 | Ubiquitination | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| S351 | Phosphorylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| T392 | Phosphorylation | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| T424 | Phosphorylation | Uniprot | |
| T445 | Phosphorylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K456 | Sumoylation | Uniprot |
研究背景
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Nucleus.
Belongs to the Sp1 C2H2-type zinc-finger protein family.
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