(2)
(2)
| 产品: | KAT8 抗体 |
| 货号: | DF13309 |
| 描述: | Rabbit polyclonal antibody to KAT8 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 52kDa; 52kD(Calculated). |
| 蛋白号: | Q9H7Z6 |
| RRID: | AB_2846328 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13309, RRID:AB_2846328.
展开/折叠
Histone acetyltransferase KAT8; Histone acetyltransferase MYST1; hMOF; K(lysine) acetyltransferase 8; KAT 8; Lysine acetyltransferase 8; MOF; MOZ; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST 1; MYST histone acetyltransferase 1; myst protein 1; MYST-1; MYST1; MYST1_HUMAN; Ortholog of Drosophila males absent on the first (MOF); Probable histone acetyltransferase MYST1; SAS2 and TIP60 protein 1; SAS2; SAS3; TIP60 protein 1; YBF2; YBF2/SAS3; ZC2HC8;
抗原和靶标
- Q9H7Z6 KAT8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9H7Z6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T14 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| Y90 | Phosphorylation | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| K113 | Acetylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| T114 | Phosphorylation | Uniprot | |
| K116 | Acetylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K168 | Acetylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| T174 | Phosphorylation | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| K177 | Acetylation | Uniprot | |
| K238 | Acetylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K274 | Acetylation | Q9H7Z6 (KAT8) | Uniprot |
| S344 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| K351 | Acetylation | Uniprot | |
| K351 | Ubiquitination | Uniprot | |
| T392 | Phosphorylation | Uniprot | |
| K410 | Ubiquitination | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| K433 | Ubiquitination | Uniprot | |
| K444 | Ubiquitination | Uniprot |
研究背景
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.
Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.
Nucleus. Chromosome.
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Interacts with MSL1; the interaction is direct. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain. Interacts with KANSL1; the interaction is direct. Interacts with MSL3. Interacts with NELFD (By similarity).
Belongs to the MYST (SAS/MOZ) family.
文献引用
Application: WB Species: mouse Sample: colonic
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