| 产品: | ETHE1 抗体 |
| 货号: | DF15261 |
| 描述: | Rabbit polyclonal antibody to ETHE1 |
| 应用: | ELISA(peptide) |
| 反应: | Human, Mouse |
| 分子量: | 28kD(Calculated). |
| 蛋白号: | O95571 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
Ethe1; ETHE1 protein, mitochondrial precursor; ETHE1_HUMAN; ethylmalonic encephalopathy 1; Ethylmalonic encephalopathy protein 1; hepatoma subtracted clone one; Hepatoma subtracted clone one protein; HSCO; mitochondrial; Protein ETHE1; Protein ETHE1 mitochondrial; YF13H12;
抗原和靶标
A synthesized peptide derived from human ETHE1.
- O95571 ETHE1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCGVQTPTA
研究背景
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.
Cytoplasm. Nucleus. Mitochondrion matrix.
Ubiquitously expressed.
Homodimer. Monomer. Interacts with TST. May interact with RELA.
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
研究领域
· Metabolism > Energy metabolism > Sulfur metabolism.
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