Ferroptosis Antibody Sampler Kit - #KF2024
产品描述
货号:
KF2024
产品:
Ferroptosis Antibody Sampler Kit
应用:
WB, IHC, IF/ICC, ELISA
反应:
Hm, Ms, Rt, Mk, Pg, Zf, Bv, Rb, Dg, Fs
产品包含:
| 货号 | 产品 | 规格 | 来源 | 应用 | 反应 | 文献引用 |
|---|---|---|---|---|---|---|
| DF6701 | GPX4 Ab | 20ul | Rabbit | WB,IHC,IF/ICC | Hm,Ms,Rt | 77 |
| DF12509 | xCT Ab | 20ul | Rabbit | WB,IHC,IF/ICC | Hm,Ms,Rt,Mk | 40 |
| DF4255 | NCOA4 Ab | 20ul | Rabbit | WB,IHC,IF/ICC | Hm,Ms,Rt | 25 |
| AF5266 | Keap1 Ab | 20ul | Rabbit | WB,IHC,IF/ICC | Hm,Ms,Rt,Mk | 35 |
| AF0639 | Nrf2 Ab | 20ul | Rabbit | WB,IHC,IF/ICC | Hm,Ms,Rt | 142 |
| DF7468 | SLC3A2 Ab | 20ul | Rabbit | WB,IHC | Hm,Rt | 2 |
| DF6278 | FTH1 Ab | 20ul | Rabbit | WB,IHC,IF/ICC | Hm,Ms,Rt | 51 |
| DF12740 | SLC11A2 Ab | 20ul | Rabbit | WB,IHC | Hm,Ms,Rt | 1 |
| AF7018 | beta Actin Ab | 20ul | Rabbit | WB,IHC,IF/ICC | Hm,Ms,Rt,Pg,Zf,Bv,Rb,Dg,Mk,Fs | 744 |
| S0001 | Goat Anti-Rabbit IgG HRP | 100ul | Goat | WB,IHC,ELISA | Rb | 506 |
简介:
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. Unlike apoptosis or necrosis, ferroptosis specifically involves the accumulation of lipid hydroperoxides, which ultimately leads to cell membrane damage and cell death.
One of the key proteins involved in regulating ferroptosis is glutathione peroxidase 4 (GPX4). GPX4 is an enzyme that plays a crucial role in protecting cells from oxidative damage by catalyzing the reduction of lipid hydroperoxides to their corresponding alcohols. In the context of ferroptosis, GPX4 acts as a critical antioxidant defense mechanism by scavenging lipid peroxides and preventing the accumulation of toxic lipid species.
However, inhibition or depletion of GPX4 results in the accumulation of lipid hydroperoxides, leading to ferroptotic cell death. This process can be triggered by various factors, including depletion of the antioxidant glutathione, inhibition of the cystine/glutamate antiporter system (system Xc-), or direct inhibition of GPX4 activity by small molecules such as RSL3.
Understanding the role of GPX4 and other key proteins in regulating ferroptosis is essential for elucidating the molecular mechanisms underlying this unique form of cell death and developing potential therapeutic interventions for diseases associated with dysregulated cell death processes.
储存条件:
Store at -20 °C. Stable for 12 months from date of receipt.
限制条款
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